|
KMID : 0923620150150050241
|
|
Immune Network
2015 Volume.15 No. 5 p.241 ~ p.251
|
|
|
Galectin-9 is Involved in Immunosuppression Mediated by Human Bone Marrow-derived Clonal Mesenchymal Stem Cells
|
|
:Kim Si-na
:Lee Hyun-Joo/:Jeon Myung-Shin/:Yi Tac-Ghee
|
|
|
Abstract
|
|
|
|
Bone marrow-derived mesenchymal stem cells (MSCs) have immunomodulatory properties and can suppress exaggerated pro-inflammatory immune responses. Although the exact mechanisms remain unclear, a variety of soluble factors are known to contribute to MSC-mediated immunosuppression. However, functional redundancy in the immunosuppressive properties of MSCs indicates that other uncharacterized factors could be involved. Galectin-9, a member of the β-galactoside binding galectin family, has emerged as an important regulator of innate and adaptive immunity. We examined whether galectin-9 contributes to MSC-mediated immunosuppression. Galectin-9 was strongly induced and secreted from human MSCs upon stimulation with pro-inflammatory cytokines. An in vitro immunosuppression assay using a knockdown approach revealed that galectin-9-deficient MSCs do not exert immunosuppressive activity. We also provided evidence that galectin-9 may contribute to MSC-mediated immunosuppression by binding to its receptor, TIM-3, expressed on activated lymphocytes, leading to apoptotic cell death of activated lymphocytes. Taken together, our findings demonstrate that galectin-9 is involved in MSC-mediated immunosuppression and represents a potential therapeutic factor for the treatment of inflammatory diseases.
|
|
|
KEYWORD
|
|
|
Human mesenchymal stem cells, Immunosuppression, Galectin-9, Apoptosis, TIM-3
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
   
|